9 Unusual Symptoms That Could Be Rheumatoid Arthritis

Rheumatoid arthritis pain and inflammation affect more than just your joints. Here are some RA symptoms you might not expect.
9 Unusual Symptoms That Could Be Rheumatoid Arthritis
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Joint pain is the hallmark symptom of rheumatoid arthritis, but this disease can attack healthy tissue throughout the body, in places where you may not expect it. Symptoms that may seem weird or unusual to you could be signs of RA. RA symptoms and their severity vary from person to person and may stop for a period, only to return later.

Here are several lesser-known — but sometimes serious — symptoms that can come with rheumatoid arthritis.

Medical Illustration about Unexpected Ways RA Affects the Body. Woman center surrounded by symptoms including fatigue, dry eyes, carpal tunnel syndrome, rash, foot and ankle pain, bruising, chest pain, everyday health logo bottom left corner
Beyond joint pain, these are some of the lesser-known symptoms of rheumatoid arthritis.Everyday Health

1. Bruising Easily

Autoimmune diseases like RA can cause your blood platelet count to dip below the normal level. Essentially, because of RA, your body uses or destroys platelets faster than it produces them, which can cause you to bruise more easily. Certain medications taken for RA, like the corticosteroid prednisone, are also known to increase the likelihood of bruising, according to Johns Hopkins Medicine.

"Your doctor can conduct a physical exam and do a complete blood count to determine whether you have low platelet levels due to the disease or to medication, and perhaps recommend treatment alternatives," says Rochelle Rosian, MD, a rheumatologist with Cleveland Clinic in Vero Beach, Florida.

2. Allover Weakness or Fatigue

What doctors call anemia of chronic disease (ACD) shouldn’t be confused with iron-deficiency anemia, the most common form of this condition. Common signs of ACD include weakness, fatigue, pale skin, fast heartbeat, and shortness of breath. ACD is the second most common form of anemia, notes the National Institutes of Health (NIH).

As the name suggests, it’s associated with chronic diseases, autoimmune inflammatory disorders like RA and lupus, and cancer.

In both ACD and iron-deficiency anemia, there are low levels of iron circulating in the blood. In ACD, however, blood iron levels are low even though stored iron levels are normal or high, according to the NIH. This occurs because inflammatory conditions like RA interfere with the way the body uses stored iron and iron from diet.

Your doctor can order a complete blood count to determine whether you have ACD. Typically, doctors will focus on treating the chronic illness that’s causing ACD. For people with ACD caused by RA, that means treating the underlying inflammation, possibly with disease-modifying antirheumatic drugs (DMARDs).

3. Skin Conditions

RA can even affect your skin. People with RA may develop rheumatoid nodules — lumps of tissue under the skin. These are local sites of inflammation, typically on the elbows, hands, and feet. While rheumatoid nodules have affected up to 30 percent of people with RA in the past, the prevalence appears to be decreasing due to earlier and more aggressive treatment of RA.

Painful sores on the hands and feet can be caused by a more serious condition related to RA — vasculitis, or inflammation of blood vessels. In rare cases, these inflamed blood vessels can actually stop blood flow, notes Cleveland Clinic.

See your doctor if you have RA and show signs of possible vasculitis, which can be detected through a biopsy.

4. Itchy and Dry Eyes

Eye conditions like keratoconjunctivitis sicca, or dry-eye syndrome, are relatively common in people who have RA. Dry eye, which can cause blurred vision, occurs more often in women than in men, notes the American Academy of Ophthalmology.

Talk to your ophthalmologist (eye doctor) about treatment if you have dry eyes. You may want to invest in a humidifier, or consider preservative-free eye drops.

"Start with over-the-counter lubricating ones, but if these don't help, ask your ophthalmologist about a prescription for immunosuppressive eye drops like Restasis (cyclosporine)," says Jonathan Greer, MD, a rheumatologist with Arthritis & Rheumatology Associates of Palm Beach in Florida.

5. Sharp Chest Pain

RA inflammation can cause chest pain that isn’t related to your heart or cardiovascular system. Irritation of the costosternal joints — those that connect your ribs to your breastbone — can be very painful, and because it’s common to think of a heart attack when chest pain is present, it can be a scary experience. But this kind of pain is not the result of a heart condition. It’s called costochondritis, being related to joint pain, rather than cardiac problems. Still, chest pain in RA needs medical attention. Doctors diagnose costochondritis with a thorough physical exam and rule out any other causes of chest pain.

Once chest pain is diagnosed as costochondritis, the recommended treatment is usually to take an over-the-counter pain reliever such as acetaminophen (Tylenol) or ibuprofen (Advil, Motrin).

The pain typically goes away on its own, notes Mayo Clinic, but may continue for a few weeks or sometimes longer.

An ice pack or a heating pad may relieve symptoms. And physical therapy might provide additional pain relief. Also, avoid any activities or movements that strain the chest area and increase your pain.

If these efforts don’t help, corticosteroid injections to ease inflammation are another potential treatment option. These are administered directly into the area where the joint is inflamed.

If you’re experiencing chest pain, however, don’t simply assume it’s costochondritis; it’s important to seek medical attention because people with RA are at an increased risk for cardiovascular disorders, including heart attacks.

And in rare cases, chest pain in people with RA can be due to pericarditis (swelling and inflammation of the tissue surrounding the heart)

as well as pleuritis (inflammation of the pleura, the tissue between your lungs and your chest wall).

6. Soreness in Your Ankles and Feet

RA can cause problems in the ankle and foot, including pain, sore joints, redness, swelling and inflammation, or warmth. Treatments may involve medication such as DMARDs, physical therapy, different footwear, braces, orthotics, or surgery. Some of the foot issues that can be caused by RA include bunions, hammertoe, bursitis, Charcot arthropathy (neuropathy which can lead to an inability to sense injuries, resulting in deformity), plantar fasciitis, rheumatoid nodules, and heel pain.

7. A Sensation of Prickling or Numbness in Your Hands

If your hands feel like they’re burning or numb, it may be a sign of carpal tunnel syndrome (CTS), which is a problem with the nerve that runs from the wrist to the fingers. CTS often occurs in people who have RA, according to the patient advocacy and support group CreakyJoints.

Talk to your physician right away if you notice changes in how your hands feel. There’s no reason to live with pain or discomfort from CTS, and treatment helps preserve hand function. CTS treatment may include wrist splints worn at night, steroid injections, adjustments to RA medication, or less commonly, surgery that helps release the pressure on the nerves in the hands.

8. Brain Fog

The Arthritis Foundation notes that people with RA report having memory issues and problems focusing, forgetting things like names and scheduled appointments. While it’s not a diagnosable condition, this fuzzy, foggy feeling known as brain fog, may be more common in RA and other forms of inflammatory arthritis.

Research suggests that inflammatory activity caused by RA is linked to cognitive impairment. There are a number of risk factors that may be at play. To stay sharp, it’s important to get good sleep, discuss your medications with your doctor, exercise regularly, manage your stress, and consider cognitive therapies like mindfulness meditation.

9. Raynaud’s Syndrome

Raynaud’s syndrome affects blood circulation, causing blood vessels to narrow more than usual in reaction to cold temperatures, and resulting in your fingers and toes turning pale (white, blue, or red) and feeling numb.

Raynaud’s syndrome can occur on its own, known as primary Raynaud’s syndrome. But secondary Raynaud’s disease can happen as the result of RA.

There’s no cure, but certain medications can help, as can lifestyle modifications, including exercising, managing stress, dressing warmly, and avoiding rapid temperature changes.

When to See a Healthcare Provider

If you’re experiencing any of the symptoms discussed above, it’s worth speaking with your doctor, especially if these unusual symptoms are persistent or worsening or if they’re affecting your daily life. It’s particularly important to seek medical care if you’re also experiencing joint pain or swelling along with any of these symptoms.

 And if chest pain occurs, it’s necessary to bring it to the attention of your doctor.

Keep track of your symptoms in a journal; note when the symptoms started, if or when they get worse, and what, if anything, seems to trigger them. Your primary care doctor may refer you to a rheumatologist who can identify and diagnose RA.

The Takeaway

  • The pain and inflammation of rheumatoid arthritis can affect more than just your joints.
  • Some of the more unusual or unexpected symptoms of RA include bruising easily, fatigue, eye problems, skin involvement, brain fog and chest pain, among others.
  • If you notice any of these symptoms, especially if they’re persistent or get worse, check in with your doctor.
EDITORIAL SOURCES
Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
Resources
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  5. Costochondritis. Mayo Clinic. May 11, 2022.
  6. Costochondritis. Cleveland Clinic. November 30, 2023.
  7. Rheumatoid Arthritis and Heart Disease. Arthritis Foundation. February 11, 2022.
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