The Consumer’s Guide to Flu Vaccines
Each fall, medical experts recommend that nearly everyone 6 months or older be vaccinated against the flu — before flu season is in full swing. (Flu cases typically start to ramp up in October.)
The flu shot has been around since the 1940s and been proven every year since to be the most effective way to prevent infection with the influenza virus. But there are lots of misunderstandings and misconceptions about it.
Maybe you’re a fan of the flu shot and never miss a season, or maybe you’re wary of it, simply forget about it, or figure you won’t get sick — and that it won’t be so bad if you do. No matter which category you’re in, learning all you can about the vaccine can help you make informed decisions going forward.
How Does the Flu Vaccine Work?
Which Flu Strains Does the Vaccine Protect Against?
The flu vaccine is updated every year to match the specific strains of the influenza virus experts predict will be most prominent during flu season. To determine this, the World Health Organization (WHO) Global Influenza Surveillance and Response System (GISRS), made up of 129 WHO member states, conducts year-round surveillance to determine which flu strains are actively circulating around the globe.
“These flu experts try to anticipate what the dominant strains are going to be nine months down the road,” explains William Schaffner, MD, a professor of infectious diseases at Vanderbilt University School of Medicine in Nashville, Tennessee. “They’re often on target, but on some occasions, the flu virus that circulates varies from the vaccine. How effective the influenza vaccine is changes from year to year, too.”
In other words, flu virus experts have to base their recommendations on a moving target, which means the vaccine can’t be perfect. Even so, according to the Centers for Disease Control and Prevention (CDC), when the flu shot and circulating viruses are a good match, it helps lower the risk of needing to see a doctor for the flu by 40 to 60 percent.
All available flu vaccines for the 2024–2025 season target three strains of influenza:
- H1N1, a subtype of influenza A
- H3N2, a subtype of influenza A
- Victoria lineage virus, a subtype of influenza B
5 Essential Facts About the Flu Vaccine
1. There are several types of flu vaccine.
A wide variety of flu vaccines are available for the 2024–2025 flu season, all of which fall into one of the following categories:
- Standard dose: An egg-based vaccine for ages 6 months and up
- Cell based: An egg-free vaccine for ages 6 months and up
- Recombinant: An egg-free vaccine for ages 18 and up
- Antigen high dose: An egg-based option for ages 65 and up that’s designed to stimulate a stronger immune response
- Adjuvanted: Another egg-based option available for ages 65 and up that’s designed to stimulate a stronger immune response
- Live attenuated influenza nasal mist: Available for ages 2 to 49; not safe for people who are pregnant or have a compromised immune system, because it’s made from a live virus
Work with your doctor to help determine the best vaccine for you.

2. Even healthy people should get a flu shot.
The flu is more of a risk for some people, including children under age 2, people 65 and older, and people who have certain health conditions or are immunocompromised. But anyone can have complications from the flu — or even die from it. No matter how young and healthy you are, the best way to prevent a serious outcome from the flu is to get vaccinated. And you won’t be protecting only yourself: By being vaccinated, you’ll help protect people who can’t safely get a flu shot.

3. Vaccination is not a guarantee you won’t get sick. But if you do, it still has benefits.
“Even if the flu vaccine isn’t perfectly matched with the dominant strain that’s circulating, that’s no reason to not get vaccinated,” says Dr. Schaffner.
Why? According to the CDC, even if you come down with the flu after you get a flu shot, it’s likely your symptoms won’t be as severe as if you weren’t vaccinated.

4. You won’t be protected from the flu immediately after you get vaccinated.
It takes two weeks for your body to build immunity against the influenza virus. That means it’s possible to come down with the flu during the window of time between the shot and when immunity fully takes hold. That’s why experts recommend getting vaccinated in fall, before the virus starts to circulate in earnest. By the time it does, if you’re vaccinated, your immune system will be primed to protect you.

5. You need a flu shot every year.
This is for two reasons, according to Andrew Pekosz, PhD, a professor of molecular microbiology and immunology at Johns Hopkins University Bloomberg School of Public Health in Baltimore.
“The first is, the flu vaccine is updated every year, based on changes in the viruses that are circulating. So, to get the maximum protection against what we think will be the dominant viruses, you need to get your vaccine every year,” he explains. “The second is, the flu vaccine response does wane over time. So you really need an extra dose every year to give you maximum protection from severe infection.”

Flu Shot FAQs
Who Should and Shouldn’t Get a Flu Shot?
“In regards to influenza, the recommendation could not be simpler: Most healthy people over 6 months old should be vaccinated,” says Schaffner.
This guidance comes with rare exceptions.
According to the CDC, it’s safe for people with an egg allergy to get a flu shot — even if it’s egg based. But people who have allergies to some other substances may not be good candidates for a flu shot. So, if you have allergies, talk to your doctor before you get vaccinated.
Which Vaccine Is Best for Me?

Different vaccines are recommended for various age groups, pregnant people, and people who are immunocompromised or have certain health conditions.
Work with your doctor to determine which vaccine is the right match for you and how to access it. You should also discuss which vaccine to get if the recommended version is unavailable to you.
At the end of the day, the goal is to get as many people vaccinated as possible. “We want you to protect yourself, your family, and your community,” says Schaffner. “Please get vaccinated.”
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- History of the Influenza Vaccine. World Health Organization.
- Key Facts About Seasonal Flu Vaccine. Centers for Disease Control and Prevention. September 17, 2024.
- Explaining How Vaccines Work. Centers for Disease Control and Prevention. August 10, 2024.
- Carter D. T Cells, B Cells and the Immune System. MD Anderson Cancer Center. November 10, 2021.
- Global Influenza Surveillance and Response System (GISRS). World Health Organization.
- Benefits of the Flu Vaccine. Centers for Disease Control and Prevention. August 14, 2024.
- CDC Recommends Updated 2024–2025 COVID-19 and Flu Vaccines for Fall/Winter Virus Season. Centers for Disease Control and Prevention. June 27, 2024.
- People at Increased Risk for Flu Complications. Centers for Disease Control and Prevention. September 11, 2024.
- Does It Matter Which Arm Gets a Vaccine? Maybe, Maybe Not. Columbia University Irving Medical Center. February 26, 2024.
- Flu Shot: Your Best Bet for Avoiding Influenza. Mayo Clinic. October 4, 2024.
- What Is a Flu Shot? NewYork-Presbyterian.
- Flu Season. Centers for Disease Control and Prevention. September 9, 2024.
- Flu Vaccines and People With Egg Allergies. Centers for Disease Control and Prevention. September 17, 2024.
- Guillain-Barré Syndrome (GBS) and Vaccines. Centers for Disease Control and Prevention. July 31, 2024.
- Is Getting a Flu Shot While Sick Risky? Cleveland Clinic. October 22, 2021.