MASH and Your Lifestyle: Which Changes Make the Biggest Impact?
Managing MASH Means Changing My Lifestyle
When you have metabolic dysfunction–associated steatohepatitis (MASH), making healthy lifestyle changes is one of the best things you can do to manage the condition and preserve liver health.
What’s more, the right habits can not only help you manage MASH, but also benefit your entire body. They can also help you manage comorbidities such as high blood pressure, high cholesterol, obesity, and type 2 diabetes, says Kara Wegermann, MD, a gastroenterologist and transplant hepatologist at Duke Health in Durham, North Carolina, and a volunteer for the American Liver Foundation.
Not sure where to start? These tips can help.
What I Wish I Knew: Focus on Sustainable Changes

Certain lifestyle changes can help you manage MASH and your overall health. Starting small can help you stick to your goals.
- Weight loss: If you're overweight, losing just 5 to 7 percent of your body weight can help improve your liver health. “Sometimes people feel like they need to lose 80 pounds, but your initial weight loss goal can be much more modest and still offer improvements,” says Dr. Wegermann. For example, if you weigh 200 pounds, 5 percent of your body weight would be 10 pounds.
- Diet modifications: Following a Mediterranean diet is often recommended for MASH. It focuses on fresh fruits and vegetables, lean proteins, legumes, whole grains, and healthy fats, such as olive oil and fatty fish, and also limits saturated fats and processed foods. If overhauling your diet seems intimidating, start small by avoiding sweet beverages, reducing snacking, and substituting empty carbs for higher protein options, says Wegermann.
- Exercise: Aim for at least 150 minutes of moderate-intensity activity, such as brisk walking or biking, each week. “People often feel like that means they have to go to the gym for 30 minutes a day … but that’s hard to do right off the bat,” says Wegermann. “So, if you have 10 minutes, do 10 minutes. That’s better than zero minutes.” Not to mention, you don’t even have to go to the gym: Taking a walk counts as exercise!
What I Wish I Knew: It’s Okay to Ask for Help

These specialists can also help you navigate any roadblocks that may be preventing you from making healthy lifestyle choices. “Some of my patients live in food deserts and have trouble accessing fresh fruits and vegetables,” says Wegermann. “They may have never learned how to cook fresh food. They may be relying on fast food due to their work schedule. So there can definitely be a lot of barriers.”
What Your Doctor Wants You to Know: Start Small to Build Healthy Habits
“We say, ‘Exercise more and eat healthy,’ but I think we underestimate how hard these changes really are,” says Wegermann. “Try to start small: Take [that] 10-minute walk [mentioned above] during your lunch break. Cut out one soda. Swap chips for veggies and hummus. And build on those changes over time.”
Questions to Ask Your Doctor
- Which lifestyle changes should I prioritize to optimize liver health?
- What type of dietary plan do you recommend I follow? What foods should I eat more or less of?
- Can I still eat my favorite foods in moderation?
- How much exercise should I be getting?
- What activities are safe for me to try?
- Do I need to lose weight? If so, how much should I aim for?
- Are there any specialists I can work with to help me make these lifestyle changes?
- Are there any treatment options available that can help me manage MASH?
- Behari J et al. Dynamics of Hepatic Steatosis Resolution and Changes in Gut Microbiome With Weight Loss in Nonalcoholic Fatty Liver Disease. Obesity Science & Practice. April 2021.
- Sualeheen A et al. Mediterranean Diet for the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease in Non-Mediterranean, Western Countries: What’s Known and What's Needed? Nutrition Bulletin. December 2024.
- Stine JG et al. Physical Activity and Nonalcoholic Fatty Liver Disease: A Roundtable Statement from the American College of Sports Medicine. Medicine & Science in Sports & Exercise. September 2023.
- Zeng J et al. Therapeutic Management of Metabolic Dysfunction Associated Steatotic Liver Disease. United European Gastroenterology Journal. March 2024.
- FDA Approves First Treatment for Patients With Liver Scarring Due to Fatty Liver Disease. U.S. Food and Drug Administration. March 14, 2024.

Jonathan G. Stine, MD, MSc, FACP
Medical Reviewer
Jonathan Stine, MD, MSc, FACP, is an associate professor of medicine and public health science at Penn State in State College, Pennsylvania.
As an internationally recognized liver expert with a research and clinical focus on metabolic dysfunction–associated steatotic liver disease (MASLD) and exercise, he has authored more than 100 peer-reviewed papers, including multinational consensus guidelines.
Dr. Stine is the recipient of multiple research grants and awards from the American Association for the Study of Liver Diseases and the American Cancer Society, and has maintained continuous funding from the National Institutes of Health since 2018.
Stine is the MASLD consultant to the American College of Sports Medicine’s “Exercise is Medicine” initiative, and recently co-chaired the International Roundtable on MASLD and Physical Activity for ACSM. He serves as the Fatty Liver Program director as well as the Liver Center Research director for Penn State.
